منابع مشابه
Calmodulin N-methyltransferase. Partial purification and characterization.
The distribution, properties, and substrate specificity of S-adenosylmethionine:calmodulin (lysine) N-methyltransferse (EC 2.1.1.60, calmodulin N-methyltransferase) of the rat have been studied. This enzyme is cytosolic and is found at high levels in tissues with high levels of calmodulin and at low levels in tissues with little calmodulin. In liver, heart, and skeletal muscle, which have low l...
متن کاملHuman Calmodulin Methyltransferase: Expression, Activity on Calmodulin, and Hsp90 Dependence
Deletion of the first exon of calmodulin-lysine N-methyltransferase (CaM KMT, previously C2orf34) has been reported in two multigene deletion syndromes, but additional studies on the gene have not been reported. Here we show that in the cells from 2p21 deletion patients the loss of CaM KMT expression results in accumulation of hypomethylated calmodulin compared to normal controls, suggesting th...
متن کاملNNMT (nicotinamide N-methyltransferase)
The human NNMT gene is approximately 16,5 kb in length, consists of 3 exons and 2 introns, and is mapped to chromosome 11q23.1. The first intron is 1,240 bp in length, while the second is approximately 14 kb long. The sequence of the 5'-untranslated region (UTR) of the NNMT cDNA is present in exon 1, while the sequence of the cDNA 3'-UTR is present in exon 3 (Aksoy et al., 1995). The initiation...
متن کاملPartial repair of deamidation-damaged calmodulin by protein carboxyl methyltransferase.
Modification of calmodulin by protein carboxyl methyltransferase requires deamidation of one or more labile asparagine residues (Johnson, B.A., Freitag, N. E., and Aswad, D. W. (1985) J. Biol. Chem. 260, 10913-10916). We now show that deamidation results in the generation of two altered forms of calmodulin, designated A and B, which can be separated by electrophoresis under nondenaturing condit...
متن کاملMolecular Identification of Carnosine N-Methyltransferase as Chicken Histamine N-Methyltransferase-Like Protein (HNMT-Like)
Anserine (beta-alanyl-N(Pi)-methyl-L-histidine), a naturally occurring derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of skeletal muscles and brain of many vertebrates. Although it has long been proposed to serve as a proton buffer, radicals scavenger and transglycating agent, its physiological function remains obscure. The formation of anserine is catalyzed by ca...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1996
ISSN: 0021-9258
DOI: 10.1074/jbc.271.22.12737